Image: Omentum was harvested from a C57BL/6 mouse and stained with anti-CD31 (green) and anti-DARC, followed by an Alexa 647 conjugated second stage (red). Whole omentum was placed between coverslips to acquire a Z-stack image using an inverted confocal microscope. Green and red images were processed and then merged.
Image: In the dermis of a mouse ear, the afferent lymphatic vessels (white) are entangled with a vast network of blood vessels (red). Dermal dendritic cells expressing class II MHC (green) are strategically positioned as immune sentinels, continuously probing the microenvironment, including extracellular spaces and into the lumen of the afferent lymph vessel. CD31+ endothelial cells (red) and LYVE-1+ lymphatic endothelial cells (white) delineate the blood vessels and lymphatic vessels, respectively. Cellular nuclear are stained blue with DAPI.Image: In the dermis of a mouse ear, the afferent lymphatic vessels (white) are entangled with a vast network of blood vessels (red). Dermal dendritic cells expressing class II MHC (green) are strategically positioned as immune sentinels, continuously probing the microenvironment, including extracellular spaces and into the lumen of the afferent lymph vessel. CD31+ endothelial cells (red) and LYVE-1+ lymphatic endothelial cells (white) delineate the blood vessels and lymphatic vessels, respectively. Cellular nuclear are stained blue with DAPI.
Dendritic cells are the "shakers and movers" of the immune system. They detect pathogens and then get the immune response rolling by activating T cells. Dendritic cells in the skin and other epithelial surfaces are called Langerhans cells (purple). Like all dendritic cells, Langerhans cells use receptors on their cell surface (e.g., Toll receptors) to identify and uptake pathogens (red) by phagocytosis or endocytosis. Once triggered, Langerhans cells then emigrate from the epithelia into the blood or lymph to launch an adaptive immune response
Dendritic cells are the "shakers and movers" of the immune system. They detect pathogens and then get the immune response rolling by activating T cells. Dendritic cells in the skin and other epithelial surfaces are called Langerhans cells (purple). Like all dendritic cells, Langerhans cells use receptors on their cell surface (e.g., Toll receptors) to identify and uptake pathogens (red) by phagocytosis or endocytosis. Once triggered, Langerhans cells then emigrate from the epithelia into the blood or lymph to launch an adaptive immune response.une response rolling by activating T cells. Dendritic cells in the skin and other epithelial surfaces are called Langerhans cells (purple). Like all dendritic cells, Langerhans cells use receptors on their cell surface (e.g., Toll receptors) to identify and uptake pathogens (red) by phagocytosis or endocytosis. Once triggered, Langerhans cells then emigrate from the epithelia into the blood or lymph to launch an adaptive immune response.
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