segunda-feira, 16 de agosto de 2010

Th9


Você sabia que tem Th9? Então leia o artigo da Immunity

IRF4 crucially contributes to the development and function of Th9 cells
IRF4 binds to and transactivates the Il9 promoter in Th9 cells
IL-9 production of human Th9 cells is accompanied by the expression of IRF4
Th9 cells crucially contribute to the pathogenesis of asthma

Summary
Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper 2 (Th2) and Th17 cells. Herein, we report that IRF4 is also crucial for the development and function of an interleukin-9 (IL-9)-producing CD4+ T cell subset designated Th9. IRF4-deficient CD4+ T cells failed to develop into IL-9-producing Th9 cells, and IRF4-specific siRNA inhibited IL-9 production in wild-type CD4+ T cells. Chromatin-immunoprecipitation (ChIP) analyses revealed direct IRF4 binding to the Il9 promoter in Th9 cells. In a Th9-dependent asthma model, neutralization of IL-9 substantially ameliorated asthma symptoms. The relevance of these findings is emphasized by the fact that the induction of IL-9 production also occurs in human CD4+ T cells accompanied by the upregulation of IRF4. Our data clearly demonstrate the central function of IRF4 in the development of Th9 cells and underline the contribution of this T helper cell subset to the pathogenesis of asthma.

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http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WSP-50N9H0K-2-X&_cdi=7052&_user=685730&_pii=S1074761310002797&_coverDate=07/30/2010&_sk=%23TOC%237052%239999%23999999999%2399999%23FLA%23display%23Articles_in_Press%23tagged%23Volume%23first%3D0%23date%23(30_July_2010)%23&view=c&_gw=y&wchp=dGLbVtz-zSkWA&md5=858e8a5a762ade419274ea4718d9686a&ie=/sdarticle.pdf

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