domingo, 1 de agosto de 2010

Os 7 mais lidos trabalhos de imunologia

Voce que gosta e trabalha em imunologia já leu algum desses trabalhos apontados pelo The Scientist como os 7 mais lidos?

Top 7 immunology papers
Posted by Edyta Zielinska
[Entry posted at 20th July 2010 02:13 PM GMT]
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#1 A gene for autoimmunity

Defective sialic acid acetylesterase (SIAE) -- an enzyme involved in the regulation of B lymphocyte signaling -- infers a greater risk of autoimmune disorders, such as rheumatoid arthritis and type I diabetes, and may contribute to the pathogenesis of such diseases.

I. Surolia et al., "Functionally defective germline variants of sialic acid acetylesterase in autoimmunity," Nature, 466:243-7, 2010. Eval by Mark Anderson, UCSF Diabetes Center; Anthony DeFranco, University of California, San Francisco; Takeshi Tsubata, Tokyo Medical University, Japan.

Follicular dendritic cell
Image: Aszakal via Wikimedia Commons
#2 Stem cells cater to infection

When a host is infected by malaria, blood stem cells produce a new kind of progenitor that is better equipped to fight the disease, suggesting that some stem cells may be able to tailor their progeny to the disease the body is facing.

N.N. Belyaev et al., "Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria," Nat Immunol, 11:477-85, 2010. Eval by Jessy Deshane and David Chaplin, Univ of Alabama at Birmingham; Christian Engwerda Queensland Institute of Medical Research.

#3 Memory cells do more than remember

Memory T cells -- which, as key players in the adaptive immune response, help the body fight repeat infections -- also activate cytokines that are part of the innate immune response, even in the absence of generic innate triggers, suggesting a new role for memory cells and a new mechanism for some autoimmune diseases.

T.M. Strutt et al., "Memory CD4+ T cells induce innate responses independently of pathogen," Nat Med May, 16:558-64, 2010. Eval by Michael McChesney, UCSD; Damian Turner and Donna Farber, Columbia Univ. Medical Center; Linda Bradley Burnham Institute for Medical Research; Jay Kolls, Lousianna State Univ. Health Sciences Centre.

#4 Gut adapts to new settlers

When new varieties of commensal bacteria enter the gut, the immune system quickly switches gears, first attacking then accepting the new settlers, suggesting that gut immunity differs from other arms of the immune system, which continue aggression if a new pathogen persists.

S. Hapfelmeier, et al., "Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses," Science, 328:1705-9 2010. Eval by Lora Hooper, Univ. of Texas Southwestern Medical Center; Denise A Kaminski and Troy Randall, Univ. of Rochester; Anthony DeFranco UCSF.

#5 Clues to how dendritic cells move

Dendritic cells hunt for a pathogen by wandering around the body to search for an invader and then migrating to the lymph node to initiate the immune response. Unlike many other immune cells, which depend on chemical gradients to direct their movement, dendritic cells also use anchoring ligands to dynamically switch between random and directed migration.

K. Schumann et al., "Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells," Immunity, 32:703-13, 2010. Eval by Jens V Stein, Univ. Bern; Steve Ward Univ. of Bath; Philip Murphy National Institute of Allergy and Infectious Diseases; Xingfeng Bao and Minoru Fukuda Burnham Institute for Medical Research.

#6 What makes a killer

A single transcription factor prevents T cells from developing into natural killer cells that can kill tumor cells, offering a potentially new way to generate large numbers of tumor-killing cells for cancer immunotherapy.

P. Li et al., "Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion," Science, 329:85-9, 2010. Eval by Eric Vivier Centre d'Immunologie de Marseille-Luminy; Deepta Bhattacharya Washington Univ. in St. Louis; Brittany Teague-Weber and Avinash Bhandoola Univ. of Pennsylvania.

#7 Creating a new helper cell

A transcription factor plays a role in the development of a new type of helper T cell, which may be involved in allergic inflammation. The results will help researchers characterize this new addition to the ever-expanding immune cell family.

H. C. Chang "The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation," Nat Immunol, 11:527-34, 2010. Eval by Dan Conrad Virginia Commonwealth University; Yrina Rochman and Warren Leonard National Institutes of Health; Amnon Altman Institute for Allergy and Immunology.

The F1000 Top 7 is a snapshot of the highest ranked articles from a 30-day period on Faculty of 1000 Immunology, as calculated on July 15, 2010. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit

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