quarta-feira, 16 de junho de 2010

Sessão Cientifica Especial

Neta quinta feira teremso a visita e apresentação do Prof Marco Brotto, BSN, MS, PhD - Associate Professor of UMKC

Email: brottom@umkc.edu
Biography: Dr. Brotto's research focuses on understanding the cellular and molecular basis of the excitation-contraction coupling process in skeletal and cardiac muscles. Two areas of his research are specifically devoted to an in-depth understanding of muscle fatigue and muscle aging. Dr. Brotto utilizes a multidisciplinary approach in his research efforts and uses a number of knockout and transgenic animals to achieve his goals.What drew me to the area of muscle physiology research was my childhood. Growing up among teachers, professors and inventors was a special gift and ever since I was child I became interested in how muscles worked. Later in life my interest in muscles became focused on how to improve human health, because healthier muscles always translate into healthier Recent Publications:
Zhao X, Weisleder N, Thornton A, Oppong Y, Campbell R, Ma J, Brotto M. Compromised store-operated Ca2+ entry in aged skeletal muscle. Aging Cell. 2008 Aug;7(4):561-8.

Brotto, M, Weisleder, N; Ma, J. Store-operated Calcium Entry in Muscle Physiology. Current Chemical Biology, 1, 87-95, 2007, Invited Review

Zhao X, Weisleder N, Han X, Pan Z, Parness J, Brotto M, Ma J. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. J Biol Chem. 2006 Nov 3;281(44):33477-86.

Brotto M, Weisleder N, Komazaki S, Pan Z, Zhao X, Nosek T, Parness J, Takeshima H, Ma J. Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release. J Cell Biol. 2006 Aug 28;174(5):639-45.

Brotto M, Hirata Y, Weisleder N, Chu Y, Lin P, Zhao X, Thornton A, Komazaki S, Takeshima H, Ma J, Pan Z. Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes. Biophys J. 2006 Jun 15;90(12):4418-27.

Brotto M, Biesiadecki BJ, Brotto LS, Nosek TM, Jin JP. Coupled expression of troponin T and troponin I isoforms in single skeletal muscle fibers correlates with contractility. Am J Physiol Cell Physiol. 2006 Feb;290(2):C567-76.

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