domingo, 20 de novembro de 2011

Gama Delta e IL17 nas inflamações da pele - Immunity

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

Immunity, Volume 35, Issue 4, 596-610, 06 October 2011
Copyright © 2011 Elsevier Inc. All rights reserved.



Interleukin-23 (IL-23) and CD4+ T helper 17 (Th17) cells are thought to be critical in psoriasis pathogenesis. Here, we report that IL-23 predominantly stimulated dermal γδ T cells to produce IL-17 that led to disease progression. Dermal γδ T cells constitutively expressed the IL-23 receptor (IL-23R) and transcriptional factor RORγt. IL-17 production from dermal γδ T cells was independent of αβ T cells. The epidermal hyperplasia and inflammation induced by IL-23 were significantly decreased in T cell receptor δ-deficient (Tcrd−/−) and IL-17 receptor-deficient (Il17ra−/−) mice but occurred normally in Tcra−/− mice. Imiquimod-induced skin pathology was also significantly decreased in Tcrd−/− mice. Perhaps further promoting disease progression, IL-23 stimulated dermal γδ T cell expansion. In psoriasis patients, γδ T cells were greatly increased in affected skin and produced large amounts of IL-17. Thus, IL-23-responsive dermal γδ T cells are the major IL-17 producers in the skin and may represent a novel target for the treatment of psoriasis.
 PDF 2.71 MB

Nenhum comentário:

Postar um comentário