quarta-feira, 21 de abril de 2010

Artigo interessante sobre Leishmaniose

Recomendo a leitura do artigo da Colega Alda Cruz do IOC. A revista publicado tem impacto alto 5,6 e demonstra a qualidade deste artigo. O PDF para os interesados pode ser pedido por e mail para alda@ioc.fiocruz.br

Microbial Antigens Can Migrate to Human Leishmaniasis Skin Lesions Alda M. Da-Cruz1, Manoel P. Oliveira-Neto2, A´ lvaro L. Bertho3, Carolina O. Mendes-Aguiar1 and Sergio G. Coutinho

Immunopathological studies have contributed to the characterization of in situ inflammatory infiltrates in cutaneous leishmaniasis (CL). However, little is known about the T-cell antigen reactivity of these lesions. Our objective was to analyze the responsiveness of lymphocytes from CL lesions to leishmanial and nonrelated antigens in terms of proliferation and the production of cytokines. Mononuclear cells were extracted from lesions, and blood from CL patients infected with Leishmania (Viannia) braziliensis. Activated cells accounted for 35–45% of lesions T-cell subsets. Elevated levels of C1.7/CD244þCD8þ T cells suggest in situ cytotoxic effector function. Lymphocytes isolated from the leishmaniasis lesions proliferated and produced IFN-g in response to leishmanial antigens as well as to irrelevant antigens such as Toxoplasma gondii (Tg). Patients presenting with larger lesions had the highest lymphocyte proliferation indexes. A high frequency of Tg-specific cells was detected in the lesions by limiting dilution assay, similar to the frequency of Leishmania-specific cells. Importantly, Tg-reactive cells were not found in lesions of patients without a history of toxoplasmosis. The proportion of Leishmania-reactive CD4þ and CD8þ T cells in the lesions was quite variable. Overall, these data suggest that T cells reactive to nonrelevant antigens can migrate to leishmanial lesions and possibly influence the pathogenesis of the disease.
Journal of Investigative Dermatology advance online publication, 28 January 2010

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